MitoPlantRedoxV1, Main, Exploration, bibRecord, 000233

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.

Identifieur interne : 000233 ( Main/Exploration ); précédent : 000232; suivant : 000234

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.

Auteurs : Kate Ina Va Ková [République tchèque] ; Ivana Marková [République tchèque] ; Jana Jašprová [République tchèque] ; Aleš Dvo K [République tchèque] ; Iva Subhanová [République tchèque] ; Jaroslav Zelenka [République tchèque] ; Iva Novosádová [République tchèque] ; Jan Rasl [République tchèque] ; Tomáš Vomastek [République tchèque] ; Roman Sobotka [République tchèque] ; Lucie Muchová [République tchèque] ; Libor Vítek [République tchèque]

Source :

Oxidative medicine and cellular longevity [ 1942-0994 ] ; 2018.

RBID : pubmed:30057678

Descripteurs français

KwdFr :
- Antinéoplasiques (pharmacologie), Antioxydants (métabolisme), Chlorophylle (pharmacologie), Disulfure de glutathion (métabolisme), Extracellular Signal-Regulated MAP Kinases (métabolisme), Glutathion (métabolisme), Heme oxygenase (decyclizing) (métabolisme), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Mitochondries (effets des médicaments et des substances chimiques), Mitochondries (métabolisme), Oxydoréduction (effets des médicaments et des substances chimiques), Peroxyde d'hydrogène (métabolisme), Phéophytines (métabolisme), Réaction de polymérisation en chaine en temps réel (MeSH), Superoxydes (métabolisme), Survie cellulaire (effets des médicaments et des substances chimiques), Synechocystis (composition chimique), Tumeurs du pancréas (métabolisme).
MESH :
- composition chimique : Synechocystis.
- effets des médicaments et des substances chimiques : Mitochondries, Oxydoréduction, Survie cellulaire.
- métabolisme : Antioxydants, Disulfure de glutathion, Extracellular Signal-Regulated MAP Kinases, Glutathion, Heme oxygenase (decyclizing), Mitochondries, Peroxyde d'hydrogène, Phéophytines, Superoxydes, Tumeurs du pancréas.
- pharmacologie : Antinéoplasiques, Chlorophylle.
- Humains, Lignée cellulaire tumorale, Réaction de polymérisation en chaine en temps réel.

English descriptors

KwdEn :
- Antineoplastic Agents (pharmacology), Antioxidants (metabolism), Cell Line, Tumor (MeSH), Cell Survival (drug effects), Chlorophyll (pharmacology), Extracellular Signal-Regulated MAP Kinases (metabolism), Glutathione (metabolism), Glutathione Disulfide (metabolism), Heme Oxygenase (Decyclizing) (metabolism), Humans (MeSH), Hydrogen Peroxide (metabolism), Mitochondria (drug effects), Mitochondria (metabolism), Oxidation-Reduction (drug effects), Pancreatic Neoplasms (metabolism), Pheophytins (metabolism), Real-Time Polymerase Chain Reaction (MeSH), Superoxides (metabolism), Synechocystis (chemistry).
MESH :
- chemical , metabolism : Antioxidants, Extracellular Signal-Regulated MAP Kinases, Glutathione, Glutathione Disulfide, Heme Oxygenase (Decyclizing), Hydrogen Peroxide, Pheophytins, Superoxides.
- chemical , pharmacology : Antineoplastic Agents, Chlorophyll.
- chemistry : Synechocystis.
- drug effects : Cell Survival, Mitochondria, Oxidation-Reduction.
- metabolism : Mitochondria, Pancreatic Neoplasms.
- Cell Line, Tumor, Humans, Real-Time Polymerase Chain Reaction.

Abstract

Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds which are structurally related to heme and bilirubin (a bile pigment with antioxidant activity) are among those molecules which are purportedly responsible for these effects. Therefore, the aim of our study was to assess both the antiproliferative and antioxidative effects of chlorophylls (chlorophyll a/b, chlorophyllin, and pheophytin a) in experimental pancreatic cancer. Chlorophylls have been shown to produce antiproliferative effects in pancreatic cancer cell lines (PaTu-8902, MiaPaCa-2, and BxPC-3) in a dose-dependent manner (10-125 μmol/L). Chlorophylls also have been observed to inhibit heme oxygenase (HMOX) mRNA expression and HMOX enzymatic activity, substantially affecting the redox environment of pancreatic cancer cells, including the production of mitochondrial/whole-cell reactive oxygen species, and alter the ratio of reduced-to-oxidized glutathione. Importantly, chlorophyll-mediated suppression of pancreatic cancer cell viability has been replicated in in vivo experiments, where the administration of chlorophyll a resulted in the significant reduction of pancreatic tumor size in xenotransplanted nude mice. In conclusion, this data suggests that chlorophyll-mediated changes on the redox status of pancreatic cancer cells might be responsible for their antiproliferative and anticancer effects and thus contribute to the decreased incidence of cancer among individuals who consume green vegetables.

DOI: 10.1155/2018/4069167
PubMed: 30057678
PubMed Central: PMC6051000

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000194
to stream Main, to step Curation: 000194

Le document en format XML

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<author><name sortKey="Novosadova, Iva" sort="Novosadova, Iva" uniqKey="Novosadova I" first="Iva" last="Novosádová">Iva Novosádová</name>
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<author><name sortKey="Vomastek, Tomas" sort="Vomastek, Tomas" uniqKey="Vomastek T" first="Tomáš" last="Vomastek">Tomáš Vomastek</name>
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<author><name sortKey="Vitek, Libor" sort="Vitek, Libor" uniqKey="Vitek L" first="Libor" last="Vítek">Libor Vítek</name>
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<affiliation wicri:level="3"><nlm:affiliation>4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</nlm:affiliation>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (pharmacology)</term>
<term>Antioxidants (metabolism)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Cell Survival (drug effects)</term>
<term>Chlorophyll (pharmacology)</term>
<term>Extracellular Signal-Regulated MAP Kinases (metabolism)</term>
<term>Glutathione (metabolism)</term>
<term>Glutathione Disulfide (metabolism)</term>
<term>Heme Oxygenase (Decyclizing) (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Hydrogen Peroxide (metabolism)</term>
<term>Mitochondria (drug effects)</term>
<term>Mitochondria (metabolism)</term>
<term>Oxidation-Reduction (drug effects)</term>
<term>Pancreatic Neoplasms (metabolism)</term>
<term>Pheophytins (metabolism)</term>
<term>Real-Time Polymerase Chain Reaction (MeSH)</term>
<term>Superoxides (metabolism)</term>
<term>Synechocystis (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques (pharmacologie)</term>
<term>Antioxydants (métabolisme)</term>
<term>Chlorophylle (pharmacologie)</term>
<term>Disulfure de glutathion (métabolisme)</term>
<term>Extracellular Signal-Regulated MAP Kinases (métabolisme)</term>
<term>Glutathion (métabolisme)</term>
<term>Heme oxygenase (decyclizing) (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Mitochondries (effets des médicaments et des substances chimiques)</term>
<term>Mitochondries (métabolisme)</term>
<term>Oxydoréduction (effets des médicaments et des substances chimiques)</term>
<term>Peroxyde d'hydrogène (métabolisme)</term>
<term>Phéophytines (métabolisme)</term>
<term>Réaction de polymérisation en chaine en temps réel (MeSH)</term>
<term>Superoxydes (métabolisme)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Synechocystis (composition chimique)</term>
<term>Tumeurs du pancréas (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term>
<term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Glutathione</term>
<term>Glutathione Disulfide</term>
<term>Heme Oxygenase (Decyclizing)</term>
<term>Hydrogen Peroxide</term>
<term>Pheophytins</term>
<term>Superoxides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Chlorophyll</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Synechocystis</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Synechocystis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term>
<term>Mitochondria</term>
<term>Oxidation-Reduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Mitochondries</term>
<term>Oxydoréduction</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term>
<term>Disulfure de glutathion</term>
<term>Extracellular Signal-Regulated MAP Kinases</term>
<term>Glutathion</term>
<term>Heme oxygenase (decyclizing)</term>
<term>Mitochondries</term>
<term>Peroxyde d'hydrogène</term>
<term>Phéophytines</term>
<term>Superoxydes</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Chlorophylle</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Lignée cellulaire tumorale</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds which are structurally related to heme and bilirubin (a bile pigment with antioxidant activity) are among those molecules which are purportedly responsible for these effects. Therefore, the aim of our study was to assess both the antiproliferative and antioxidative effects of chlorophylls (chlorophyll <i>a</i>
/<i>b</i>
, chlorophyllin, and pheophytin <i>a</i>
) in experimental pancreatic cancer. Chlorophylls have been shown to produce antiproliferative effects in pancreatic cancer cell lines (PaTu-8902, MiaPaCa-2, and BxPC-3) in a dose-dependent manner (10-125 <i>μ</i>
mol/L). Chlorophylls also have been observed to inhibit heme oxygenase (HMOX) mRNA expression and HMOX enzymatic activity, substantially affecting the redox environment of pancreatic cancer cells, including the production of mitochondrial/whole-cell reactive oxygen species, and alter the ratio of reduced-to-oxidized glutathione. Importantly, chlorophyll-mediated suppression of pancreatic cancer cell viability has been replicated in <i>in vivo</i>
 experiments, where the administration of chlorophyll <i>a</i>
 resulted in the significant reduction of pancreatic tumor size in xenotransplanted nude mice. In conclusion, this data suggests that chlorophyll-mediated changes on the redox status of pancreatic cancer cells might be responsible for their antiproliferative and anticancer effects and thus contribute to the decreased incidence of cancer among individuals who consume green vegetables.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30057678</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1942-0994</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>2018</Volume>
<PubDate><Year>2018</Year>
</PubDate>
</JournalIssue>
<Title>Oxidative medicine and cellular longevity</Title>
<ISOAbbreviation>Oxid Med Cell Longev</ISOAbbreviation>
</Journal>
<ArticleTitle>Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.</ArticleTitle>
<Pagination><MedlinePgn>4069167</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1155/2018/4069167</ELocationID>
<Abstract><AbstractText>Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds which are structurally related to heme and bilirubin (a bile pigment with antioxidant activity) are among those molecules which are purportedly responsible for these effects. Therefore, the aim of our study was to assess both the antiproliferative and antioxidative effects of chlorophylls (chlorophyll <i>a</i>
/<i>b</i>
, chlorophyllin, and pheophytin <i>a</i>
) in experimental pancreatic cancer. Chlorophylls have been shown to produce antiproliferative effects in pancreatic cancer cell lines (PaTu-8902, MiaPaCa-2, and BxPC-3) in a dose-dependent manner (10-125 <i>μ</i>
mol/L). Chlorophylls also have been observed to inhibit heme oxygenase (HMOX) mRNA expression and HMOX enzymatic activity, substantially affecting the redox environment of pancreatic cancer cells, including the production of mitochondrial/whole-cell reactive oxygen species, and alter the ratio of reduced-to-oxidized glutathione. Importantly, chlorophyll-mediated suppression of pancreatic cancer cell viability has been replicated in <i>in vivo</i>
 experiments, where the administration of chlorophyll <i>a</i>
 resulted in the significant reduction of pancreatic tumor size in xenotransplanted nude mice. In conclusion, this data suggests that chlorophyll-mediated changes on the redox status of pancreatic cancer cells might be responsible for their antiproliferative and anticancer effects and thus contribute to the decreased incidence of cancer among individuals who consume green vegetables.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vaňková</LastName>
<ForeName>Kateřina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marková</LastName>
<ForeName>Ivana</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jašprová</LastName>
<ForeName>Jana</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dvořák</LastName>
<ForeName>Aleš</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0002-1285-6928</Identifier>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Subhanová</LastName>
<ForeName>Iva</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zelenka</LastName>
<ForeName>Jaroslav</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Novosádová</LastName>
<ForeName>Iva</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rasl</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vomastek</LastName>
<ForeName>Tomáš</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sobotka</LastName>
<ForeName>Roman</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muchová</LastName>
<ForeName>Lucie</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0003-2082-1060</Identifier>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vítek</LastName>
<ForeName>Libor</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0002-5318-0151</Identifier>
<AffiliationInfo><Affiliation>Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>07</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Oxid Med Cell Longev</MedlineTA>
<NlmUniqueID>101479826</NlmUniqueID>
<ISSNLinking>1942-0994</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010674">Pheophytins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>11062-77-4</RegistryNumber>
<NameOfSubstance UI="D013481">Superoxides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1406-65-1</RegistryNumber>
<NameOfSubstance UI="D002734">Chlorophyll</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>603-17-8</RegistryNumber>
<NameOfSubstance UI="C061694">pheophytin a</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>BBX060AN9V</RegistryNumber>
<NameOfSubstance UI="D006861">Hydrogen Peroxide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.14.14.18</RegistryNumber>
<NameOfSubstance UI="D006419">Heme Oxygenase (Decyclizing)</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber>
<NameOfSubstance UI="D048049">Extracellular Signal-Regulated MAP Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>GAN16C9B8O</RegistryNumber>
<NameOfSubstance UI="D005978">Glutathione</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>ULW86O013H</RegistryNumber>
<NameOfSubstance UI="D019803">Glutathione Disulfide</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002734" MajorTopicYN="N">Chlorophyll</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D048049" MajorTopicYN="N">Extracellular Signal-Regulated MAP Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005978" MajorTopicYN="N">Glutathione</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019803" MajorTopicYN="N">Glutathione Disulfide</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006419" MajorTopicYN="N">Heme Oxygenase (Decyclizing)</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006861" MajorTopicYN="N">Hydrogen Peroxide</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010190" MajorTopicYN="N">Pancreatic Neoplasms</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010674" MajorTopicYN="N">Pheophytins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013481" MajorTopicYN="N">Superoxides</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046939" MajorTopicYN="N">Synechocystis</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>01</Month>
<Day>09</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>02</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>04</Month>
<Day>19</Day>
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<affiliations><list><country><li>République tchèque</li>
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<name sortKey="Dvo K, Ales" sort="Dvo K, Ales" uniqKey="Dvo K A" first="Aleš" last="Dvo K">Aleš Dvo K</name>
<name sortKey="Jasprova, Jana" sort="Jasprova, Jana" uniqKey="Jasprova J" first="Jana" last="Jašprová">Jana Jašprová</name>
<name sortKey="Markova, Ivana" sort="Markova, Ivana" uniqKey="Markova I" first="Ivana" last="Marková">Ivana Marková</name>
<name sortKey="Muchova, Lucie" sort="Muchova, Lucie" uniqKey="Muchova L" first="Lucie" last="Muchová">Lucie Muchová</name>
<name sortKey="Novosadova, Iva" sort="Novosadova, Iva" uniqKey="Novosadova I" first="Iva" last="Novosádová">Iva Novosádová</name>
<name sortKey="Rasl, Jan" sort="Rasl, Jan" uniqKey="Rasl J" first="Jan" last="Rasl">Jan Rasl</name>
<name sortKey="Sobotka, Roman" sort="Sobotka, Roman" uniqKey="Sobotka R" first="Roman" last="Sobotka">Roman Sobotka</name>
<name sortKey="Subhanova, Iva" sort="Subhanova, Iva" uniqKey="Subhanova I" first="Iva" last="Subhanová">Iva Subhanová</name>
<name sortKey="Vitek, Libor" sort="Vitek, Libor" uniqKey="Vitek L" first="Libor" last="Vítek">Libor Vítek</name>
<name sortKey="Vitek, Libor" sort="Vitek, Libor" uniqKey="Vitek L" first="Libor" last="Vítek">Libor Vítek</name>
<name sortKey="Vomastek, Tomas" sort="Vomastek, Tomas" uniqKey="Vomastek T" first="Tomáš" last="Vomastek">Tomáš Vomastek</name>
<name sortKey="Zelenka, Jaroslav" sort="Zelenka, Jaroslav" uniqKey="Zelenka J" first="Jaroslav" last="Zelenka">Jaroslav Zelenka</name>
</country>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000233 | SxmlIndent | more

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{{Explor lien
   |wiki=    Bois
   |area=    MitoPlantRedoxV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30057678
   |texte=   Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30057678" \
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This area was generated with Dilib version V0.6.38.
Data generation: Sat Nov 21 12:18:52 2020. Site generation: Sat Nov 21 12:19:22 2020

	Serveur d'exploration sur les mitochondries dans l'oxydoréduction chez les plantes
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les mitochondries dans l'oxydoréduction chez les plantes

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects.

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